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Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity |
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| Authors: | Matthew N Davies Channa K Hattotuwagama David S Moss Michael GB Drew Darren R Flower |
| Institution: | (1) Edward Jenner Institute for Vaccine Research, Compton, Newbury, RG20 7NN, UK;(2) School of Crystallography, Birkbeck College, London, WC1E 7HX, UK;(3) Structural and Computational Chemistry Group, University of Reading, Reading, RG6 6AH, UK |
| Abstract: | BackgroundMHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide binding prediction have largely concentrated on the peptide anchor residues located at the P2 and C-terminus positions. |
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