Modeling Sage data with a truncated gamma-Poisson model |
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Authors: | Helene H Thygesen Aeilko H Zwinderman |
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Institution: | (1) Clinical Epidemiology and Biostatistics, Academisch Medisch Centrum, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands |
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Abstract: | Background Serial Analysis of Gene Expressions (SAGE) produces gene expression measurements on a discrete scale, due to the finite number
of molecules in the sample. This means that part of the variance in SAGE data should be understood as the sampling error in
a binomial or Poisson distribution, whereas other variance sources, in particular biological variance, should be modeled using
a continuous distribution function, i.e. a prior on the intensity of the Poisson distribution. One challenge is that such
a model predicts a large number of genes with zero counts, which cannot be observed. |
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