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Parameters of proteome evolution from histograms of amino-acid sequence identities of paralogous proteins |
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| Authors: | Jacob Bock Axelsen Koon-Kiu Yan Sergei Maslov |
| Affiliation: | 1. Center for Models of Life, Niels Bohr Institute, Blegdamsvej 17, DK-2100, Copenhagen ?, Denmark 2. Department of Condensed Matter Physics and Materials Science, Brookhaven National Laboratory, Upton, New York, 11973, USA 3. Department of Physics and Astronomy, Stony Brook University, Stony Brook, New York, 11794, USA |
| Abstract: | BackgroundThe evolution of the full repertoire of proteins encoded in a given genome is mostly driven by gene duplications, deletions, and sequence modifications of existing proteins. Indirect information about relative rates and other intrinsic parameters of these three basic processes is contained in the proteome-wide distribution of sequence identities of pairs of paralogous proteins. |
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