Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66 |
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Authors: | JianLan You XiaoLi Xue LiXiang Cao Xin Lu Jian Wang LiXin Zhang |
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Affiliation: | (1) State Key Laboratory for Biocontrol, College of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, People’s Republic of China;(2) Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510663, People’s Republic of China;(3) Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100080, People’s Republic of China;(4) South China Sea Institute of Oceanology, CAS, 510301 Guangzhou, People’s Republic of China;(5) SynerZ Pharmaceuticals, Lexington, MA, USA |
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Abstract: | China remains by far the largest aquaculture producer in the world. However, biofilms formed by pathogenic Vibrio strains pose serious problems to marine aquaculture. To provide a strategy for biofilm prevention, control, and eradication, extracts from 88 marine actinomycetes were screened. Thirty-five inhibited the biofilm formation of Vibrio harveyi, Vibrio vulnificus, and Vibrio anguillarum at a concentration of 2.5% (v/v). Thirty-three of the actinomycete extracts dispersed the mature biofilm. Six extracts inhibited the quorum-sensing system of V. harveyi by attenuating the signal molecules N-acylated homoserine lactones’ activity. Strain A66, which was identified as Steptomyces albus, both attenuated the biofilms and inhibited their quorum-sensing system. It is suggested that strain A66 is a promising candidate to be used in future marine aquaculture. |
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Keywords: | Vibrio biofilm Quorum sensing Biocontrol |
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