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Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice
Authors:Ankit X. Sharma  Ezekiel B. Quittner-Strom  Young Lee  Joshua A. Johnson  Sarah A. Martin  Xinxin Yu  Jianping Li  John Lu  Zheqing Cai  Shiuhwei Chen  May-yun Wang  Yiyi Zhang  Mackenzie J. Pearson  Andie C. Dorn  Jeffrey G. McDonald  Ruth Gordillo  Hai Yan  Dung Thai  William L. Holland
Affiliation:1. Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA;2. Department of Molecular Genetics, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA;3. Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA;4. Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8549, USA;5. Medical Service, Veteran’s Administration North Texas Health Care System, Dallas, TX 75216, USA;6. REMD Biotherapeutics Inc., Camarillo, CA 93012, USA;7. Cardio-lab, Baltimore, MD 21205, USA
Abstract:
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  • Keywords:ceramide  lipotoxicity  adiponectin  sphingolipid
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