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Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility
Authors:Chizu Tanikawa  Koji Ueda  Akari Suzuki  Aritoshi Iida  Ryoichi Nakamura  Naoki Atsuta  Genki Tohnai  Gen Sobue  Naomi Saichi  Yukihide Momozawa  Yoichiro Kamatani  Michiaki Kubo  Kazuhiko Yamamoto  Yusuke Nakamura  Koichi Matsuda
Institution:1. Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan;2. Project for Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Tokyo 135-8550, Japan;3. RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan;4. Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan;5. Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan;6. Departments of Medicine and Surgery and Center for Personalized Therapeutics, The University of Chicago, Chicago, IL 60637, USA;7. Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo 108-8639, Japan
Abstract:
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  • Keywords:PAD4  citrulline  methylation  ALS  protein aggregation  SNP  TAF15  FUS  EWS  hnRNP
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