Tumor necrosis factor induces acute phase proteins in rats |
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| Authors: | I Gresser F Delers N Tran Quangs S Marion R Engler C Maury C Soria J Soria W Fiers J Tavernier |
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| Institution: | Lab. Viral Oncology, CNRS, Villejuif, France. |
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| Abstract: | Inoculation of WAG rats with recombinant mouse tumor necrosis factor results in a rapid and marked increase in several acute phase proteins in the serum (haptoglobin, alpha 1 acid glycoprotein, alpha 2 macroglobulin) and in the plasma (fibrinogen). We conclude that TNF may play an important role in the inflammatory response in vivo and possibly in the pathogenesis of inflammatory disorders. |
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