DeTEKting ubiquitination of APC/C substrates |
| |
Authors: | Haas Arthur L Wilkinson Keith D |
| |
Institution: | Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA. |
| |
Abstract: | Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|