Isolation of two murine H1 histone genes and chromosomal mapping of the H1 gene complement |
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Authors: | B Drabent K Franke C Bode U Kosciessa H Bouterfa H Hameister D Doenecke |
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Institution: | (1) Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany;(2) Abteilung Medizinische Genetik, Universität Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany |
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Abstract: | The mammalian H1 histone gene complement consists of at least seven H1 protein isoforms. These include five S-phase-dependent H1 protein subtypes and two more distantly related proteins, which are expressed upon terminal differentiation (H10) or during the pachytene stage of spermatogenesis (H1t). In the past, three replication-dependent murine H1 genes plus the H1
0 and H1t genes have been isolated and characterized. In this report, we describe the sequences of two more H1 genes, and we show that all five murine replication-dependent H1 genes and the H1t gene map to the region A2-3 on Chromosome (Chr) 13. This is in agreement with our previous finding that the human H1 histone gene complement maps to 6p21.3, which corresponds to the A2-3 region on the murine Chr 13. Previous reports have shown that the replication-independent H1
0 genes map to syntenic regions on Chrs 22 (human H10) and 15 (murine H1
0). |
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