Evaluation of a high-density oligonucleotide array for characterization of grlA, grlB, gyrA and gyrB mutations in fluoroquinolone resistant Staphylococcus aureus isolates |
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| Authors: | Couzinet Sabine Yugueros Javier Barras Christine Visomblin Nathalie Francois Patrice Lacroix Bruno Vernet Guy Lew Daniel Troesch Alain Schrenzel Jacques Jay Corinne |
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| Institution: | Division of Infectious Diseases, University Hospitals of Geneva, CH-1211, 24 rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. corinne.jay@eu.biomerieux.com |
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| Abstract: | Using high-density oligonucleotide array technology, 30 Staphylococcus aureus strains were studied for the presence of mutations in genes involved in fluoroquinolone resistance: grlA, gyrA, grlB and gyrB. For the two most important genes, gyrA and grlA, correlation with sequencing reached 95.1%. If all genes were considered, correlation was 88.8%. |
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