Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells |
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Authors: | Shojaei Farbod Wu Xiumin Malik Ajay K Zhong Cuiling Baldwin Megan E Schanz Stefanie Fuh Germaine Gerber Hans-Peter Ferrara Napoleone |
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Affiliation: | Genentech, Inc., 1 DNA Way, S. San Francisco, California 94080, USA. farbod@gene.com |
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Abstract: | Vascular endothelial growth factor (VEGF) is an essential regulator of normal and abnormal blood vessel growth. A monoclonal antibody (mAb) that targets VEGF suppresses tumor growth in murine cancer models and human patients. We investigated cellular and molecular events that mediate refractoriness of tumors to anti-angiogenic therapy. Inherent anti-VEGF refractoriness is associated with infiltration of the tumor tissue by CD11b+Gr1+ myeloid cells. Recruitment of these myeloid cells is also sufficient to confer refractoriness. Combining anti-VEGF treatment with a mAb that targets myeloid cells inhibits growth of refractory tumors more effectively than anti-VEGF alone. Gene expression analysis in CD11b+Gr1+ cells isolated from the bone marrow of mice bearing refractory tumors reveals higher expression of a distinct set of genes known to be implicated in active mobilization and recruitment of myeloid cells. These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells. |
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