Induction of diabetes by PolyI:C and anti-RT6.1 antibody treatment in DR-BB rats. |
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| Authors: | N Nakamura Y Tsutsumi S Kimata M Sawada G Hasegawa Y Kitagawa K Nakano M Kondo H Nakao S Makino |
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| Institution: | First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan. |
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| Abstract: | To determine whether environmental factors could affect the incidence of diabetes in RT6.1+ lymphocytes-depleted diabetes resistant (DR) BB rats, we tested polyinosinic-polycytidylic acid (Poly I:C), as an immune activator, in conjunction with anti-RT6.1 antibody in DR-BB rats which were bred in a specific pathogen free (SPF) condition. Diabetes was induced by the combined administration of poly I:C and anti-RT6.1 antibody. The use of poly I:C or anti-RT6.1 antibody alone did not cause diabetes. These results suggest that RT6.1+ T lymphocytes regulate autoimmune diabetes and that non-specific immune activation caused by environmental factors plays a key role in inducing diabetes in DR-BB rats. |
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