Recent advances in identifying and validating drug targets in trypanosomes and leishmanias |
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Authors: | Barrett M P Mottram J C Coombs G H |
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Affiliation: | Division of Infection & Immunity, University of Glasgow, UK. |
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Abstract: | The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation. |
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