Preparation of 1-acyl-2-succinyl glycero-3-phosphorylcholine and evidence against its involvement in succinate dehydrogenase action |
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| Authors: | FH Brain AN Davison V Natarjan PS Sastry |
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| Institution: | 1. (F.H.B.) Biochemistry and Chemistry Department, Guy''s Hospital Medical School, London SE1 9RT, England;2. Department of Neurochemistry, Institute of Neurology, The National Hospital, Queens Square, London WC1 3BG, England |
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| Abstract: | 1-Acyl-2-succinyl glycero-3-phosphorylcholine (GPC) was synthesized and its properties described. Although 1-acyl-2-succinyl GPC is a good substrate for succinate dehydrogenase, experiments on the incorporation of 2,3-14C]succinate into mitochondrial lipids gave no evidence to indicate that it is an intermediate in the enzymic oxidation of succinate to fumarate, as has been suggested earlier. |
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| Keywords: | To whom requests for reprints should be addressed |
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