Brain and sperm cell surface antigen (NS-4) on preimplantation mouse embryos |
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Authors: | Davor Solter Melitta Schachner |
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Affiliation: | 1. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104, USA;2. Department of Neuropathology, Harvard Medical School, Boston, Massachusetts 02115 USA;3. Department of Neuroscience, Children''s Hospital Medical Center, Boston, Massachusetts 02115 USA |
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Abstract: | Antiserum prepared in rabbit against 4-day-old mouse cerebellum (anti-NS-4 serum) reacts in the complement-mediated cytotoxicity test with unfertilized and fertilized mouse eggs, cleavage stage embryos, and cells of the trophoblast and inner cell mass of the mouse blastocyst. This activity is specifically removed by absorption of antiserum with adult mouse brain and epididymal sperm but not with adult liver, spleen, kidney, and thymocytes. The antiserum reacts most strongly with cells of the trophoblast and inner cell mass and, in order of decreasing reactivity, with four- to eight-cell stage embryos, zygotes, unfertilized eggs, and two-cell stage embryos. |
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