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In vivo covalent binding of 14CCl4 metabolites in liver microsomal lipids |
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| Authors: | E S Reynolds M T Moslen |
| Institution: | Pathology Departments, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass. 02115, U.S.A. |
| Abstract: | Covalently bound 14C from 14CCl4 is preferentially localized in the lipids of hepatic microsomes of rats within 15 min. Label was recovered in all classes of lipids isolated from the microsomal lipid extract by diethylaminoethyl column chromatography. Among phospholipids, specific activity was the highest in the fraction containing phosphatidyl serine and lowest in phosphatidyl choline. Cholesterol esters had more than ten times the specific activity of cholesterol. |
| Keywords: | TLC thin layer chromatography DEAE diethylaminoethyl PC phosphatidyl choline PE phosphatidyl ethanolamine PI phosphatidyl inositol PS phosphatidyl serine Ch cholesterol ChE cholesterol esters |
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