Crucial amides for dimerization inhibitors of HIV-1 protease |
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Authors: | Bowman Michael J Chmielewski Jean |
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Institution: | Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA. |
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Abstract: | An inhibitor based on crosslinked peptides from the interfacial region of HIV-1 protease, previously shown to act by dimerization inhibition, was modified by N-methylation to ascertain the importance of the amide hydrogens on inhibition. The effects of N-methylation on HIV-1 protease inhibition, as well as the effects on degradation by proteases are described. |
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