Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination |
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| Authors: | Che-Ming Hung Shinn-Chih Wu Chih-Ching Yen Ming-Fong Lin Yi-Wen Lai Yu-Tang Tung Hsiao-Ling Chen and Chuan-Mu Chen |
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| Institution: | (1) Department of Life Sciences, National Chung Hsing University, No. 250, Kuo Kuang Road, 402 Taichung, Taiwan;(2) Department of Animal Science and Technology, National Taiwan University, 106 Taipei, Taiwan;(3) China Medical University Hospital, 404 Taichung, Taiwan;(4) Department of Health, Taichung Hospital, 403 Taichung, Taiwan;(5) Department of Molecular Biotechnology, Da-Yeh University, 515 Changhwa, Taiwan; |
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| Abstract: | In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral
lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus.
Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated
at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method
and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in
serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-γ and IL-12 in chicken T lymphocytes.
These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent
anti-viral responses. |
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