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The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua |
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| Authors: | Pawel Basta Marcin Majka Wojciech Jozwicki Ewelina Lukaszewska Anna Knafel Marek Grabiec Elzbieta Stasienko Lukasz Wicherek |
| Affiliation: | 1.Department of Gynecology,and Oncology of the Jagiellonian University,Krakow,Poland;2.Gynecology and Oncology Department of the Lukaszczyk Oncological Center and Chair of Gynecology,Oncology and Gynecological Nursing of the Ludwik Rydygier Collegium Medicum,Bydgoszcz,Poland;3.Transplantology Department of the Jagiellonian University,Krakow,Poland;4.Department of Tumor Pathology,and Pathomorphology of the Ludwik Rydygier Collegium Medicum, Lukaszczyk Oncology Center,Bydgoszcz,Poland;5.Department of Obstetrics,Gynecology and Oncological Gynecology of the Ludwik Rydygier Collegium Medicum,Bydgoszcz,Poland |
| Abstract: | BackgroundThe presence of regulatory T (Treg) cells in human endometrium is crucial for maintaining immunological homeostasis within the uterus. For this study we decided to evaluate the subpopulations of Treg cells in conditions where a disturbance in the immunological equilibrium in ectopic endometrium and decidua has been observed, such as in cases of ovarian endometriosis (involving local immune cell suppression) and ectopic pregnancy (involving an increase in local immune system activity). We then compared these findings to what we observed in the normal eutopic endometrium of women during the secretory phase of the menstrual cycle (with immune cells under individual control). |
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