Understanding the HIV coreceptor switch from a dynamical perspective |
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Authors: | Christel Kamp |
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Institution: | (1) Paul-Ehrlich-Institut, Paul-Ehrlich-Stra?e 51-59, Langen, 63225, Germany |
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Abstract: | Background The entry of HIV into its target cells is facilitated by the prior binding to the cell surface molecule CD4 and a secondary
coreceptor, mostly the chemokine receptors CCR5 or CXCR4. In early infection CCR5-using viruses (R5 viruses) are mostly dominant
while a receptor switch towards CXCR4 occurs in about 50% of the infected individuals (X4 viruses) which is associated with
a progression of the disease. There are many hypotheses regarding the underlying dynamics without yet a conclusive understanding. |
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Keywords: | |
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