| 人同源框基因Lhx4 cDNA序列的获得,染色体定位和基因组分析 |
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| 引用本文： | 刘耀波,于顺,周严,汪家政,刘淑红,袁建刚,强伯勤,范明. 人同源框基因Lhx4 cDNA序列的获得,染色体定位和基因组分析[J]. 中国生物化学与分子生物学报, 2001, 17(5): 552-556 |
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| 作者姓名： | 刘耀波 于顺 周严 汪家政 刘淑红 袁建刚 强伯勤 范明 |
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| 作者单位： | 1. 军事医学科学院基础医学研究所
2. 中国协和医科大学基础医学研究所 |
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| 基金项目： | 国家自然科学基金资助项目(No.39970247) |
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| 摘 要： | Lhx4基因是LIM同源框基因家族的一员 ,它在运动神经元的发育过程中发挥着重要的作用 .从人脊髓cDNA文库中筛选到了 1个人源性Lhx4基因的cDNA全长序列 ,它与鼠源性的Lhx4基因的cDNA序列有 92 %同源性 .它的基因被定位在 1号染色体 1q 2 4 .1- 1q 2 4 .3的位置 ,并包含有 6个外显子 .其中同源框结构域由外显子 4和 5表达 ,LIM结构域 1由外显子 2表达 ,LIM结构域2由外显子 3表达 .
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| 关 键 词： | Lhx4基因 染色体定位 运动神经元 |
| 收稿时间： | 2001-10-20 |
| 修稿时间： | 2001-04-09 |
cDNA Isolation, Chromosomal Mapping and Genomic Analysis of Human Homeobox Gene Lhx4 |
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| LIU Yao bo ),YU Shun ),ZHOU Yan ),WANG Jia zheng ),LIU Shu hong ),YUAN Jian gang ),QIANG Bo qin ),FAN Ming ). cDNA Isolation, Chromosomal Mapping and Genomic Analysis of Human Homeobox Gene Lhx4[J]. Chinese Journal of Biochemistry and Molecular Biology, 2001, 17(5): 552-556 |
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| Authors: | LIU Yao bo ) YU Shun ) ZHOU Yan ) WANG Jia zheng ) LIU Shu hong ) YUAN Jian gang ) QIANG Bo qin ) FAN Ming ) |
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| Affiliation: | (Beijing Institute of Basic Medical Sciences, Beijing 100850,China; 1) I |
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| Abstract: | Lhx 4 gene is a member of the LIM homeobox gene family and plays a critical role in the development of motor neurons. A cDNA of human Lhx 4 gene was isolated from the cDNA library of adult human spinal cord. Its sequence was 92% homologous to that of the mouse. Its structure and chromosomal localization was identified. The gene was localized on human chromosome 1q 24.1-1q 24.3 and composed of six exons. The homeodomain was encoded by two exons, exons 4 and 5. The first LIM domain was encoded by exon 2, and the second by exon 3. |
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| Keywords: | Lhx4 gene chromosome localization motor neuron |
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