Clinical isolates of <Emphasis Type="Italic">Nocardia brasiliensis</Emphasis> from Japan exhibit variable susceptibility to the antibiotic imipenem |
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Authors: | Akiko?Kageyama Yasutaka?Hoshino Masaharu?Watanabe Katsukiyo?Yazawa Email author" target="_blank">Yuzuru?MikamiEmail author |
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Institution: | (1) Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, 260-8673 Chiba, Japan;(2) Chiba University Hospital, Chiba University, 1-8-1, Inohana, Chuo-ku, 260-8673 Chiba, Japan |
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Abstract: | Clinical isolates of Nocardia brasiliensis from Japan were classified into two groups based on their susceptibility to the carbapenem antibiotic, imipenem (IPM). Of
33 strains tested, 10 belonged to an IPM susceptible group, with MIC of from 0.25 to 2 εg/ml and a MIC80 value of 1.5 εg/ml for this antibiotic. The remaining 23 strains belonged to an IPMresistant group with MIC and MIC80 values of 8–16 εg/ml and >16 εg/ml, respectively. The type strain of N. brasiliensis belonged to this resistant group. Analysis of 16S rDNA genes sequences showed that the IPM susceptible group had characteristic
single nucleotide substitutions at positions 103 (T), 381 (A), and 456 (A), in contrast to the IPM resistant group. This grouping,
however, was not associated with their clinical manifestation. |
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Keywords: | Nocardia brasiliensis imipenem susceptibility new biotypes phylogenetic difference Japanese isolate 16S-rDNA |
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