The effect of drug concentration and curing time on processing and properties of calcium alginate beads containing metronidazole by response surface methodology |
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Authors: | Yagnesh L Patel Praveen Sher Atmaram P Pawar |
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Institution: | Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038 Pune, Maharashtra State India |
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Abstract: | The purpose of present research work was to prepare calcium alginate beads containing water-soluble drug metronidazole using
32 factorial design, with drug concentration and curing time as variables. Curing time was kept as low as possible to improve
entrapment with increasing drug concentration. Mostly the drugs which had been encapsulated were water insoluble to facilitate
drug encapsulation; a characteristic drug release as whole process is aqueous based. Entrapment efficiency was in the range
of 81% to 96% wt/wt, which decreased with decrease in polymer concentration and increase in curing time. The beads were spherical
with size range between 1.4 and 1.9 mm. Scanning electron microscope (SEM) photomicrographs revealed increase in the leaching
of drug crystals with increased curing time and high drug concentrations. In acidic environment, the swelling ratio was 200%
in 30 minutes, but in basic medium, it increased to a maximum of 1400% within 120 minutes. In acidic medium, the swelling
and drug release properties were influenced by drug solubility, whereas in phosphate buffer these properties were governed
by the gelling of polymer and exhibited curvilinear and quadratic functions of both the variables, respectively. |
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Keywords: | calcium alginate ionotropic gelling water-soluble drug curing time metronidazole |
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