Effects of tetradecanoyl phorbol acetate,pyrethroids and DDT in the V79 |
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Authors: | Lars Wärngård Sten Flodström |
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Institution: | (1) Department of Toxicology and Institute of Environmental Medicine, The Karolinska Institute, Stockholm, Sweden;(2) Istitute of Environmental Medicine, The Karolinska Institute, Box 60208, S-104 01, Stockholm, Sweden |
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Abstract: | The effects of the pyrethroids fucythrinate, cyfluthrin, bioallethrin and resmethrin on metabolic cooperation between V79 cells were investigated. Addition offucythrinate to cocultures of 6-thioguanine-resistant and 6-thioguanine-sensitive V79 cells significantly increased the mutant cell recovery, indicating inhibition of intercellular communication. No such effect was observed by the other pyrethroids tested. To compare the modes of action of TPA-, DDT-, and pyrethroid-induced inhibition of intercellular communication, co-exposure experiments were undertaken. Addition of TPA, together with increasing doses of fenvalerate or fucythrinate, produced a synergistic response. Various combinations of fenvalerate-, fucythrinate- and DDT-exposure gave results in accordance with an additive response. The result suggest different pathways of action for TPA and the insecticides investigated in this study.Abbreviations DDT
1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane
- DMSO
dimethyl sulfoxide
- 6-TG
6thioguanine
- TPA
12-0-tetradecanoyl phorbol-13-acetate |
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Keywords: | bioallethrin cyfluthrin DDT fenvalerate flucythrinate intercellular communication metabolic cooperation pyrethroids resmethrin tetradecanoyl phorbol acetate |
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