Liberation of sisomicin from cells by sodium chloride |
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Authors: | Shin Chul S Ahn Byung W Lee Sang H Kim Sung U Bok Song H |
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Institution: | (1) Life Science Division, Korea Research Institute of Chemical Technology, Daejeon, Chungnam, Korea |
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Abstract: | Summary Most sisomicin produced during fermentation by Micromonospora inyoensis remained bound inside the cells. When cells were suspended in buffer solutions containing sodium chloride, the bound antibiotic was increasingly liberated by increasing salt concentration. These results were applied to fermentation cultures and, as a result, up to 46% increase in final product titre was achieved. |
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