TBX2 expression is regulated by PAX3 in the melanocyte lineage |
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| Authors: | Jinghu Lv Liang Dong Eric Pier George X. Xu Rui‐an Wang Zhixiang Xu Colin Goding Rutao Cui |
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| Affiliation: | 1. Rizhao General Hospital, , Rizhao, Shandong Province, China;2. Department of Dermatology, Boston University School of Medicine, , Boston, MA, USA;3. Department of Pathology and Lab Medicine, University of Pennsylvania, , Philadelphia, PA, USA;4. Department of Pathology, Fourth Military Medical University, , Xian, Shanxi, China;5. Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, , Birmingham, Al, USA;6. Ludwig Institute for Cancer Research, University of Oxford, , Oxford, UK |
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| Abstract: | The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T‐box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for prosenescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2. |
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| Keywords: | T‐box 2 paired box homeotic gene 3 melanocyte |
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