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Nuclease Activity of Human Interleukin-10 |
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| Authors: | Dranitsyna S. M. Kostanyan I. A. Astapova M. V. Surina E. A. Lipkin V. M. |
| Affiliation: | (1) Russian Academy of Sciences, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, ul. Miklukho-Maklaya 16/10, GSP-7 Moscow, 117997, Russia |
| Abstract: | The nuclease activity of human interleukin-10, an immunosuppressive cytokine, was predicted on the basis of structural homology between the 97–105 sequence of human interleukin-10 and the DNA/RNA-hydrolyzing fragment of the endogenous differentiation factor for the HL-60 line of human promyelocyte leukemia cells. The human recombinant interleukin-10 was shown to cleave all forms of plasmid DNA. The role of interleukin-10 in the apoptosis induction in monocytic cells was hypothesized. |
| Keywords: | apoptosis HL-60 cells differentiation factor HLDF interleukin-1 |
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