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Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug |
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| Authors: | S Srimatkandada B I Schweitzer B A Moroson S Dube J R Bertino |
| Affiliation: | Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510. |
| Abstract: | |
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