Interleukin-1 beta increases the BCL-2/BAX ratio in Kaposi's sarcoma cells |
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Authors: | Simonart Thierry Van Vooren Jean-Paul |
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Affiliation: | Department of Dermatology, Erasme University Hospital, B-1070 Brussels, Belgium. tsimonar@ulb.ac.be |
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Abstract: | Interleukin-1 (IL-1) is a multifunctional cytokine known to act as a growth factor for AIDS-KS cells. In addition to its mitogenic effects, we found that IL-1 induced the protection of KS cells from apoptotic death induced by serum deprivation in a dose-dependent manner. AIDS-KS cells as well as cells derived from iatrogenic and sporadic KS exhibited a similar response to IL-1, which stresses the key role of this cytokine in the pathogenesis of KS regardless of its epidemiological form. Using both an immunohistochemical and an immunoblot approach, we found that IL-1 increased the expression of Bcl-2 and decreased that of Bax, while having no effect on the expression of Bclx(L), Fas and CD40. The effects of IL-1 were inhibited by IL-1ra, suggesting that imbalance between these two counter-acting cytokines may contribute to the altered accumulation of KS spindle cells. Our findings may provide a link between KS cell escape from apoptosis and the immune dysregulation known to be associated with KS. |
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Keywords: | apoptosis/IL-1/Kaposi’s sarcoma/tumour |
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