| Abstract: | The influence of propranolol on the circadian variations of duration of the anaesthetic effect of diazepam and hexobarbital sodium were studied at 2-hour intervals in two separate round-the-clock observations on mice. Propranolol significantly changed the daily course of the anaesthetic effect of diazepam, caused its inversion and reduced the mean duration of hexobarbital anaesthesia. The observed antagonism between propranolol and hypnotics with varying anaesthetic properties could be attributed to its ability to interfere with both the cerebral neuromediator sleep regulating and beta-adrenoblocking systems but not to its specific blocking effects on pineal functions. |
