Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum |
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| Authors: | Liu Jie Kurashiki Kenji Shimizu Kuniyoshi Kondo Ryuichiro |
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| Institution: | Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan. |
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| Abstract: | In humans, 5alpha-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5alpha-reductase activity. The presence of the C-3 carbonyl group and of the C-26-alpha,beta-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum. |
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| Keywords: | 5α -Reductase Ganoderma lucidum Anti-androgen activities Benign prostatic hyperplasia (BPH) |
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