Highly Conserved Caspase and Bcl-2 Homologues from the Sea Anemone Aiptasia pallida: Lower Metazoans as Models for the Study of Apoptosis Evolution |
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Authors: | Simon R Dunn Wendy S Phillips Joseph W Spatafora Douglas R Green Virginia M Weis |
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Institution: | (1) Department of Zoology, Oregon State University, Corvallis, OR 97331, USA;(2) Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA;(3) Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA |
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Abstract: | Key insight into the complexities of apoptosis may be gained from the study of its evolution in lower metazoans. In this study
we describe two genes from a cnidarian, Aiptasia pallida, that are homologous to key genes in the apoptotic pathway from vertebrates. The first is a novel ancient caspase, acasp, that displays attributes of both initiator and executioner caspases and includes a caspase recruitment domain (CARD). The
second, a Bcl-2 family member, abhp, contains a BH1 and BH2 domain and shares structural characteristics and phylogenetic affinity with a group of antiapoptotic
Bcl-2s including A1 and Bcl-2L10. The breadth of occurrence of other invertebrate homologues across the phylogenetic trees
of both genes suggests that the complexity of apoptotic pathways is an ancient trait that predates the evolution of vertebrates
and higher invertebrates such as nematodes and flies. This paves the way for establishing new lower metazoan model systems
for the study of apoptosis.
Electronic Supplementary Material Electronic Supplementary material is available for this article at
and accessible for authorised users.
Reviewing Editor: Dr. Stuart Newfeld] |
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Keywords: | Apoptosis Caspase Bcl-2 Cnidaria Anemone Aiptasia |
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