Synthesis and structure-activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists |
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| Authors: | Han Xiaojun Pin Sokhom S Burris Kevin Fung Lawrence K Huang Stella Taber Matthew T Zhang Jie Dubowchik Gene M |
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| Affiliation: | Pharmaceutical Research Institute, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA. xiaojun.han@bms.com |
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| Abstract: | 8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (K(i) = 23 nM). |
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