Correlation between the avidity maturation of anti-HSP70 IgG autoantibody and recombination activating gene expressions in peripheral lymphoid tissues of Toxoplasma gondii-infected mice |
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Authors: | Chen Mei Aosai Fumie Mun Hye-Seong Norose Kazumi Piao Lian Xun Yano Akihiko |
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Institution: | Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Chiba, Chiba 260-8670, Japan. |
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Abstract: | The avidity maturation of anti-TgHSP70 IgG antibody produced by B-2 cells of BALB/c mice (a resistant strain) and that of anti-mHSP70 IgG autoantibody produced by B-1 cells of C57BL/6 mice (B6; a susceptible strain) was observed after Toxoplasma gondii infection. Recombination-activating genes (RAGs) were predominantly expressed in B-1 cells from peritoneal exudate cells (PECs) of T. gondii-infected B6 mice, while RAGs were expressed in B-2 cells from PECs of BALB/c mice. These results suggest that the involvement of RAG gene activations in the peripheral lymphoid tissues in the avidity maturation of anti-TgHSP70 IgG antibody and anti-mHSP70 IgG autoantibody in T. gondii-infected mice. |
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Keywords: | rag toxoplasma gondii avidity maturation autoantibody |
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