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CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice
Authors:Paolo Pasquali  Angela M Thornton  Silvia Vendetti  Claudia Pistoia  Paola Petrucci  Michela Tarantino  Michele Pesciaroli  Franco Ruggeri  Andrea Battistoni  Ethan M Shevach
Institution:1. Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy;2. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA;3. Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Rome, Italy;4. Department of Biology, University of Tor Vergata, Rome, Italy;1. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX;2. Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX;3. Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center, Houston, TX;4. Hemato-Pathology Unit, The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom;5. Hemato-Oncology Unit The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom;1. Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, The University of Texas Medical School at Houston, Houston, TX, USA;2. Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX, USA;3. Daejeon Health Sciences College, Daejeon, South Korea;1. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;2. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD;3. Department of Pediatrics, University of Texas Medical School, Houston, TX;1. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, CA 94143, USA;3. Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:Brucellosis is one of the most common bacterial zoonoses worldwide. Infection is usually chronic and sometimes lifelong. Different mechanisms can be postulated as to the basis for the induction of the chronic status of brucellosis, but a comprehensive knowledge is still lacking. Here, we carried out a series of experiments in order to assess if the persistence of Brucella abortus could be ascribed to the effect of a down regulation of the immune response due to activity of regulatory T cells. We demonstrate that CD4 + CD25 + T regulatory cells are able to limit the effectiveness of CD4 + T cells and are able to favor the maintenance and the progression of B. abortus infection.
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