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New insights into molecular Ehrlichia chaffeensis-host interactions
Authors:Abdul Wakeel  Bing Zhu  Xue-jie Yu  Jere W. McBride
Affiliation:1. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;3. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;4. Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;5. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, USA;1. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, United States;2. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, United States;3. Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555-0609, United States;4. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, United States;1. Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA;2. Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA;3. ISaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), 13005 Ciudad Real, Spain;1. Institute of Chemical Biology and Fundamental Medicine, SB RAS, Novosibirsk, Russian Federation;2. Khabarovsk Antiplague Station, Khabarovsk, Russian Federation;1. Instituto de Zoonosis Luis Pasteur, Ministerio de Salud, Gobierno de la Ciudad Autónoma de Buenos Aires., Av Díaz Vélez 4821, C1405DCD CABA, Argentina;2. Instituto Nacional de Tecnología Agropecuaria, Estación Experimental Agropecuaria Rafaela and Consejo Nacional de Investigaciones Científicas y Técnicas, CC 22, CP 2300 Rafaela, Santa Fe, Argentina;1. Agricultural Research Council-Onderstepoort Veterinary Research, Private Bag X5, Onderstepoort, 0110, South Africa;2. Department of Veterinary Tropical Diseases, University of Pretoria, Private Bag X04, Onderstepoort, 0110, South Africa
Abstract:Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by reprogramming the host cell. Here we review new information regarding the newly characterized effector molecules and the complex network of molecular host–pathogen interactions that the organism exploits enabling it to thrive and persist intracellularly.
Keywords:
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