New insights regarding the biology of Giardia lamblia |
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| Authors: | Pedro G Carranza Hugo D Lujan |
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| Institution: | 1. Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy;2. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden;1. Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia;2. Melbourne Water Corporation, Victoria, Australia;3. Institute of Parasitology and Tropical Veterinary Medicine, 14163 Berlin, Germany;1. Department of Animal Biology, Faculty of Science, Damascus University, Damascus, Syria;2. Atomic Energy Commission of Syria, Department of Molecular Biology and Biotechnology, Microbiology and Immunology Division, Syria |
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| Abstract: | Giardia lamblia is one of the most common causes of intestinal disease in humans. To adapt to environments both inside and outside of the host's small intestine, this protozoan parasite undergoes significant developmental changes during its life cycle. In this review, we analyze and discuss the most recent findings regarding the process of Giardia trophozoites differentiation into infective cysts as well as the mechanism of antigenic variation, which allows the parasite to cause chronic and recurrent infections in susceptible individuals. |
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