Interleukin-21: a multifunctional regulator of immunity to infections |
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| Authors: | John S Yi Maureen A Cox Allan J Zajac |
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| Institution: | 1. Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States;2. Interdisciplinary Program in Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States;1. Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC;2. Department of Biomedical Engineering, Duke University, Durham, NC;3. The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC;4. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA;1. Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy;2. Department of Medicine and Health Science Vincenzo Tiberio, University of Molise, Campobasso, Italy |
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| Abstract: | Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections. |
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