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Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma |
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| Authors: | Itaru Hirai Tadahiro Sasaki Ai Kimoto Yoshimasa Yamamoto Takeshi Azuma Varocha Mahachai Piyathida Hansomburana Comsun Lertkupinit Somchai Luangjaru Phadet Noophan Rattikorn Chanatrirattanapan Vanich Piyanirandr Theeranan Sappajit Karun Suthivarakom Leelaowadee Sangsuk Piyada Wangroongsarb |
| Institution: | 1. Center of Gastrointestinal Endoscopy, Hue University Hospital, Viet Nam;2. Dipartimento di Scienze Biomediche, Università di Sassari, Italy;3. Department of Microbiology & Carlo Urbani Center, Hue University of Medicine & Pharmacy, Viet Nam;1. Laboratory of Structural Biology, Department of Biochemistry, Institute of Chemistry, University of São Paulo—USP, São Paulo, São Paulo, C.P. 26077, 05513-970, Brazil;2. Department of Exact Sciences and Technology, State University of Santa Cruz—UESC, Ilhéus, Bahia 45662-900, Brazil;3. Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo—USP, São Paulo, São Paulo, C.P. 26077, 05513-970, Brazil;4. Department of Biophysics, Federal University of São Paulo—UNIFESP, São Paulo, São Paulo 04044-020, Brazil |
| Abstract: | In Thailand, gastric cancer incidence is considerably low despite the high prevalence of Helicobacter pylori infection. We investigated the prevalence of H. pylori infection and the genotypes of cagA by using 179 stool specimens obtained from asymptomatic Thai individuals. In this study, the prevalence of H. pylori infection was 43.6%, and the detection rate of cagA-positive strains was 43.5%. In addition, the proportion of the highly virulent East-Asian type of cagA was 7.2%. These results indicate that the low prevalence of cagA-positive H. pylori strain as well as the low prevalence of East-Asian genotype cagA-positive strains may contribute to the low gastric cancer incidence. |
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