Exploiting the chemical synthesis of RNA. |
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Authors: | N Usman R Cedergren |
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Affiliation: | Department of Biology, Massachusetts Institute of Technology, Cambridge 02139. |
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Abstract: | A number of nucleotide phosphoramidites are now available that permit the chemical synthesis of RNA, modified RNA and RNA-DNA chimeric oligonucleotides. Since the chemical strategy allows the introduction of a particular modification at any given site in a nucleotide polymer, very subtle and specific questions regarding structure-function relationships in RNA may be addressed. |
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