Intracisternal TRH and RX 77368 Potently Activate Gastric Vagal Efferent Discharge in Rats |
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| Affiliation: | 1. CURE/UCLA Digestive Disease Center, West Los Angeles Veterans Administration Medical Center, and Department of Medicine and Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90073USA;1. Pharmacogenetics Unit, UGC Provincial de Farmacia de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Avda. Fuerzas Armadas, 2, Spain;2. Department of Biochemistry, Faculty of Pharmacy, University of Granada, Campus Universitario de Cartuja, s/n, 18071 Granada, Spain;3. Queen''s University Belfast, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Institute of Clinical Sciences, Block B, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, United Kingdom;1. Scientific Instrumentation Centre, LNEC, Av. do Brasil, 101, 1700-066 Lisbon, Portugal;2. Centre of Intelligent Systems of IDMEC, Instituto Superior Técnico – Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisbon, Portugal;1. Faculty of Pharmacy, University of Sydney, NSW, Australia;2. Priority Research Centre for Respiratory Diseases, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia;3. School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, NSW, Australia;4. Woolcock Emphysema Centre, Woolcock Institute of Medical Research, University of Sydney, NSW, Australia;5. School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, Australia |
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| Abstract: | O-Lee, T. J., J. Y. Wei and Y. TachÉ. Intracisternal Trh and Rx 77368 potently activate gastric vagal efferent discharge in rats. Peptides 18(2) 213–219, 1997.—The influence of intracisternal (ic) TRH and the stable TRH analog, RX 77368, on gastric vagal efferent discharge (GVED) was investigated in urethane-anesthetized rats. Consecutive IC injections of TRH (3, 30, and 300 ng) at 60 min intervals stimulated dose dependently multi-unit GVED with a peak increase of 90 ± 21%, 127 ± 18% and 145 ± 16% respectively. In two separate studies, IC injection of RX 77368 at 1.5 or 15 ng stimulated multi-unit GVED by 142 ± 24% and 244 ± 95% respectively. Saline injection IC had no effect on GVED. RX 77368 (1.5 ng, ic) action was long lasting (84 ± 13 min) compared with TRH (3 ng: 44 ± 7 min). Single-unit analysis also showed that 13 of 13 units responded to ic RX 77368 (1.5 ng) by an increase in activity. These data indicate that low doses of TRH injected ic stimulate vagal efferent outflow to the rat stomach and that RX 77368 action is more potent than TRH. |
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