Modality-specific organization for cutaneous and proprioceptive sense in human primary sensory cortex studied by chronic epicortical recording |
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| Institution: | 1. Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Cagliari, Italy;2. Multiple Sclerosis Centre, Binaghi Hospital, Department of Medical Sciences and Public Health, University of Cagliari, Italy;3. Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy;1. Dept. of Neurology, Albany Medical College, Albany, NY, USA;2. Neural Injury and Repair, Wadsworth Center, New York State Dept. of Health, Albany, NY, USA;3. Early Brain Injury and Motor Recovery Lab, Burke-Cornell Medical Research Institute, White Plains, NY, USA;4. Translational Neurological Research Laboratory, Helen Hayes Hospital, West Haverstraw, NY, USA;5. Dept. of Neurosurgery, Albany Medical Center, Albany, NY, USA;6. Dept. of Neurosurgery, Washington University, St. Louis, MO, USA;7. Dept. of Biomed. Eng., Rensselaer Polytechnic Institute, Troy, NY, USA;8. Dept. of Biomed. Sci., State Univ. of New York at Albany, Albany, NY, USA;9. Dept. of Elec. and Comp. Eng., Univ. of Texas at El Paso, El Paso, TX, USA |
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| Abstract: | Modality specificity of human primary somatosensory cortex was studied by recording somatosensory evoked potentials (SEPs) from subdural electrodes in a patient with intractable focal motor seizure. A newly developed device was used for selectively activating proprioception. The spatial and temporal distributions of proprioception-related SEPs elicited by brisk passive flexion movement at the proximal interphalangeal (PIP) joint of the middle finger (4 degrees in 25 ms) were quite different from those to cutaneous sense evoked by electric stimulation of the digital nerve at the same site. It was for the first time demonstrated that proprioception-related SEPs following passive finger movement do not originate in area 3b, which was clearly activated by cutaneous stimulation, and that other sites at the sensorimotor cortex such as areas 2, 3a and 4 possibly contribute to the cortical processing of proprioception. |
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