Induction of ice and inhibition of c-fos,jun D and zif 268 in 12 -month old spontaneously hypertensive rats |
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| Institution: | 2. Center for Hemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University, Hospital, Aarhus, Denmark;3. Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark;4. Department of Neurology, Danish Stroke Center, Aarhus University Hospital, Aarhus, Denmark;1. IIByT-UNC CONICET, CEBICEM, Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, Av. Vélez Sarsfield 1611, X5016GCA Córdoba, Argentina;2. Department of Biological Sciences, Rutgers University, 225 University Avenue, Newark, N.J. 07102, United States;1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Neurosurgery, Southwest Hospital, Chongqing 400038, China;1. Department of Neurology, the Jikei University School of Medicine, Tokyo, Japan;2. Department of Rehabilitation Medicine, the Jikei University School of Medicine, Tokyo, Japan |
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| Abstract: | A semi-quantitative reverse transcprition-polymerase chain reaction (RT-PCR) assay was used to examine ICE, c-fos, jun D and zif 268 mRNA expression in the aortic and renal artery of 12-month old SHRs and wistar rats. Using this assay system, it was observed that the levels of aortic and renal artery expression of ICE were markedly higher in SHRs than in wistar rats. In contrast, the aortic and renal artery expression of immediate early genes (IEGs), c-fos, jun D and zif 268, were significant lower in SHRs than in wistar rats. Thus, our results suggest that differential regulation of death gene ICE and IEGs such as c-fos, jun D and zif 268 might be involved in the mechanism of pathogenesis of hypertension. |
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