AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain |
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| Affiliation: | 1. Departments of Pharmacology, Pharmacology and Toxicology, Biochemistry, Psychiatry and the Program in Neuroscience, University of Arizona and Health Science Center, Tucson, Arizona 85724, U.S.A.;2. School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, U.S.A.;3. Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107, U.S.A.;1. Institute of Animal Immune Engineering, Jiangsu Academy of Agricultural Sciences, Nanjing, China;2. National Research Center of Engineering and Technology for Veterinary Biologicals, Jiangsu Academy of Agricultural Sciences, Nanjing, China;3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China;1. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA;2. Rodent Behavioral Core Department of Research Administration, Case Western Reserve University School of Medicine, Cleveland, OH, USA;1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China;2. Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xi’an Medical University, Xi’an, China;1. Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland;2. Center for Drug Discovery, Department of Pharmaceutical Sciences, Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, United States;3. Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United States;4. Center of Endoscopy, Starnberg, Germany and Department of Medicine 2, Ludwig-Maximilian University Munich, Munich, Germany |
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| Abstract: | AM 630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species specific. Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species Variation. |
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