Inhibition by cigarette smoke of lipid peroxidation-induced neurotransmitter release |
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| Affiliation: | 1. Seed Science Center, Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, PR China;2. Yunnan Academy of Tobacco Agricultural Sciences, Yuxi 653100, PR China;3. Yuxi Zhongyan Tobacco Seed Company Ltd., Yuxi 653100, PR China;1. Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara, SP, Brazil;2. Universidade Estadual Paulista (UNESP), Faculdade de Ciências, Bauru, SP, Brazil;1. Epidemiology Research Program, American Cancer Society, Atlanta, GA;2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA;3. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD;4. Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, WA;5. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA;1. Department of Physics, University College of Engineering Nagercoil, Anna University, Nagercoil, 629004, India;2. Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology, 500 007, Hyderabad, India;1. Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA;2. Department of Epidemiology, School of Public Health, University of Alabama, Birmingham;3. Department of Medicine, Weill Cornell Medical College, New York, NY;4. Department of Medicine, College of Medicine, University of Vermont, Burlington;5. Department of Public Health Sciences, Medical University of South Carolina, Charleston |
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| Abstract: | Effects of water-soluble substance in cigarette smoke on neurotransmitter release were investigated using nerve terminals (synaptosomes) prepared from rat cerebral cortex. 2,2′-Azobis (2-amidinopropane) dihydrochloride (ABAP), a peroxyl radical-generator, enhanced the depolarization-evoked release of glutamate and aspartate from synaptosomes with concomitant increase in thiobarbituric acid-reactive substances (TBA-RS) levels in membrane lipids of synaptosomes. The trapped smoke-substance attenuated the lipid peroxidation-enhanced release of excitatory amino acids during the depolarization with reduction in TBA-RS, although it failed to affect the basal release of neurotransmitters. These data suggest that cigarette smoke may possess antioxidant properties to reduce oxidation-induced enhancement of transmitter release from nerve terminals. |
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