Nociceptin: An endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties |
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| Affiliation: | 1. VetAgro Sup, Campus Vétérinaire de Lyon, Université de Lyon, Unité APCSe VetAgro Sup UPSP 2016.A101, Marcy l''Etoile, France;2. Faculté d''Agronomie et de Médecine Vétérinaire, Pharmacologie, Département de médecine vétérinaire, Université Libanaise, Beirut, Lebanon;3. VetAgro Sup, Campus Vétérinaire de Lyon, Université de Lyon, Anesthésiologie, Marcy l''Etoile, France;4. Hospices Civiles de Lyon, Université de Lyon, Centre Hospitalier Lyon Sud, Réanimation Médicale, Unité APCSe VetAgro Sup UPSP 2016.A101, Pierre-Bénite, France;5. Université Claude Bernard Lyon 1, Université de Lyon, Unité APCSe VetAgro Sup UPSP 2016.A101, Lyon, France |
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| Abstract: | The purpose of the present study was to investigate the effects of nociceptin on peripheral arterial rings from the cat. When feline renal, mesenteric, carotid and femoral rings with intact endothelium were precontracted with phenylephrine (100 nanomolar), nociceptin (3 × 10−11 − 3 × 10−6 M) decreased tension in a concentration-dependent manner. The present datasuggest nociceptin possesses biologic activity outside the CNS and may contribute to the regulation of systemic blood pressure and regional blood flow. |
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