Effect of azelastie on PGE2 production in fibroblasts in normal skin. the possibility of inhibition of inducible cyclooxygenase by azelastine |
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| Institution: | 1. Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;2. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;3. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;4. Department of Medical Science, Faculty of Science, Rangsit University, Patumthani 12000, Thailand;5. Faculty of Allied Health Science, Burapha University, Chonburi 20130, Thailand;1. School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, ROC;2. Division of Chinese Medicine Literature and Informatics, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC;3. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan, ROC;4. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, United States;5. Chinese Medicinal Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, ROC;6. Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan, ROC;1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China;2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, 510006, China;3. Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China;4. School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, China;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1427CWO, Ciudad Autónoma de Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Fisicoquímica, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL, UBA-CONICET), Junín 956, C1113AAD, Ciudad Autónoma de Buenos Aires, Argentina;1. Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, PR China;2. Jiangsu Key Laboratory of Marine Biotechnology, Lianyungang 2220005, PR China;3. Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, PR China;4. State Key Lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, PR China |
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| Abstract: | The effects of azelastine on prostaglandin E2 (PGE2) production were investigated by using cultured normal dermal fibroblasts obtained from the same traumatic region of 3 patients and the CRL-1475 cell line, lnterleukin-1 β (IL-1) enhanced PGE2 production in cultured normal fibroblasts and CRL-1475 cells. 10?6 M azelastine inhibited PGE2 production in these IL-1-stimulated fibroblasts. However, the drug did not influence spontaneous PGE2 production in cultured CRL-1475 fibroblasts not stimulated with IL-1 but slightly it increased in cultured normal dermal fibroblasts under the same conditions. These results suggest that azelastine either regulates synthesis of an inducible cyclooxygenase protein or inhibits PGE2 production as an inducible cyclooxygenase inhibitor. |
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