Interactions between different antidepressants and morphine alter gastrointestinal transit in mice |
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| Institution: | 1. Department of Psychiatry, the First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, China;2. Xi''an Jiaotong University Health Science Center, Xi''an, China;3. Department of Clinical Research Center, the First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, China;4. Shaanxi Belt and Road Joint Laboratory of Precision Medicine in Psychiatry, the First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, China;1. Department of Public Health, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan;2. Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan;3. Department of Psychiatry, Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan;4. Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan;5. Department of Psychiatry, Taiwan Adventist Hospital, Taipei, Taiwan;6. Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;7. Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan;8. Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan |
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| Abstract: | To determine different serotoninergic antidepressants' effects on the gastrointestinal (GI) inhibiting effect induced by morphine, mice were pretreated with mianserin (a tetracyclic antidepressant with multiple 5-HT receptor subtypes interactions) and with fluoxetine (a selective 5-HT reuptake inhibitor). Mianserin alone, produced gastrointestinal inhibition in a dosedependent manner. Naloxone did not reverse this inhibiting effect, indicating that different mechanism of action are involved in morphine- and mianserin-induced inhibition of the gastrointestinal transit. Fluoxetine injected alone produced an increased propulsive motility of the GI transit. This effect was not reversed by naloxone. Fluoxetine did not reduce significantly mianserin-induced inhibition of GI transit. Fluoxetine also mildly reversed morphine-induced gastrointestinal inhibition, suggesting some degree of involvement of the opiates through the serotoninergic system. |
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