Increased apoptosis of adult rat lymphocytes after single neonatal vitamin a treatment (hormonal imprinting). A flow cytometric analysis |
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| Institution: | 1. Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, H-1445 Budapest, POB 370, Hungary;2. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, H-1445 Budapest, POB 370, Hungary;1. Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;2. Dermatologic Unit, University of L''Aquila, L''Aquila, Italy;3. Dermatology Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy;4. Microbiology Section, Department of Experimental Medicine and Surgery, University of Rome “Tor Vergata”, Rome, Italy;5. Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy;1. Amsterdam UMC, Department of Molecular Cell Biology and Immunology, Research Institute of Amsterdam Institute for Infection and Immunity, Vrije Universiteit, Amsterdam, The Netherlands;2. Amsterdam UMC, Department of Surgery, Research Institute of Amsterdam Institute for Infection and Immunity, Vrije Universiteit, Amsterdam, The Netherlands |
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| Abstract: | Newborn rats were treated with a single dose of vitamin A (retinol) and apoptosis of peripheral lymphocytes was studied by flow cytometry in adult age. Vitamin A treatment (hormonal imprinting) caused a moderate, however significant elevation in the number of apoptotic lymphocytes after three months. Dexamethasone or Concanavalin-A alone did not influence apoptosis significantly. However, in the neonatally retinol treated rats dexamathasone significantly elevated the quantity of apoptotic lymphocytes related to the control or Concanavalin-A treated control cells. The results call attention to the prolonged effect of hormonal imprinting in a new index and to the possible dangerous effects in human, neonatally treated with vitamin A. |
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