Modulation of cAMP-dependent protein kinase by derivatives of chondroitin sulfate |
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| Institution: | 1. Department of Oral and Craniofacial Sciences, School of Dentistry, and Center for Excellence in Mineralized and Dental Tissues, University of Missouri–Kansas City, Kansas City, MO, United States;2. Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, MI, United States;1. Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic;2. Department of Physics and Measurements, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic |
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| Abstract: | Here, we report investigations about the direct effect of glycosaminoglycans, such as dermatan sulfate, chondroitin 4- and 6-sulfate upon cAMP-dependent protein kinase activity. The results indicate that glycosaminoglycans strongly influence the phosphorylation activity of this enzyme against histone type IIa and Val6,Ala7]-kemptide. While chondroitin 4-sulfate and dermatan sulfate exhibit inhibitory effects, chondroitin 6-sulfate shows a stimulating effect. In addition, the chondroitin 6-sulfate is also able to reduce the chondroitin 4-sulfate and dermatan sulfate specific inhibition. |
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